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John Murdoch (Rufus Sewell) awakens alone in a strange hotel to find he is wanted for a series of brutal murders. His memories have vanished and even his beautiful wife Emma (Jennifer Connelly) has become estranged from him. So begins a quest to unravel the mysteries of his pact; a quest that will take him into a fiendish underworld where he is relentlessly pursued by the police and a gang of shadow-like beings known as the Strangers and where only the sinister Doctor Schrebe  
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